KDR (kinase insert domain receptor)/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)
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چکیده
منابع مشابه
Kinase insert domain receptor/vascular endothelial growth factor receptor 2 (KDR) genetic variation is associated with ovarian hyperstimulation syndrome
BACKGROUND The objective of this investigation was to determine if kinase insert domain/vascular endothelial growth factor receptor 2 (KDR/VEGFR2) genetic variation was associated with the development of ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation (COH). METHODS This was a case-control study of 174 patients who underwent controlled ovari...
متن کاملVascular endothelial cell growth factor-driven endothelial tube formation is mediated by vascular endothelial cell growth factor receptor-2, a kinase insert domain-containing receptor.
Vascular endothelial cell growth factor (VEGF) binds to 2 related receptor tyrosine kinases, known as kinase insert domain-containing receptor (KDR) and fms-like tyrosine kinase (Flt-1). The KDR has been shown to mediate VEGF-stimulated endothelial cell mitogenesis, migration, and permeability. The Flt-1 receptor has been suggested to mediate VEGF-stimulated endothelial branching morphogenesis,...
متن کاملassociation of kinase insert domain-containing receptor (kdr) gene polymorphism/ haplotypes with recurrent spontaneous abortion and genetic structure
background: recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society. recently a few numbers of genetic polymorphisms in kinase insert domain-containing receptor (kdr) gene are examined that can endanger the life of the fetus in pregnant women. objective: the risk of kdr gene polymorphisms was inves...
متن کاملP-105: Genetic Variation of Kinase Insert Domain-Containing Receptor Gene and Its Association with Recurrent Spontaneous Abortion
Background Recurrent spontaneous abortion has been defined two or more consecutive miscarriages at 20 weeks pregnancy and one of diseases that can lead to physical, psychological and economical for the individual problems. Recently number of polymorphisms in several genes was examined for association analyses in pregnant women which related to endanger the life of the fetus. In present study we...
متن کاملThe antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells.
Itraconazole is a safe and widely used antifungal drug that was recently found to possess potent antiangiogenic activity. Currently, there are four active clinical trials evaluating itraconazole as a cancer therapeutic. Tumor growth is dependent on angiogenesis, which is driven by the secretion of growth factors from the tumor itself. We report here that itraconazole significantly inhibited the...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2018
ISSN: 1768-3262
DOI: 10.4267/2042/66055